10,000 units of vitamin D

Joanne started with a 25-hydroxy vitamin D level of 23 ng/ml–severe deficiency.

What made this starting value even worse was that it was drawn in August after a moderately sunny summer spent outdoors. (Last summer, not this summer.) It therefore represented her high for the year, since vitamin D levels trend lower as fall and winter set in. This suggests that her winter level was likely in the teens or even single digits. In addition, note that, at age 43, Joanne has lost much of her ability to activate vitamin D in the skin.

So I advised that she take 6000 units of an oil-based gelcap per day, a dose likely to generate the desired blood level, which I believe is 60-70 ng/ml.

Four months later, her 25-hydroxy vitamin D level: 39.9 ng/ml–still too low. So I advised her to increase her dose to 10,000 units per day. Several months later, her 25-hydroxy vitamin D level: 63.8 ng/ml–perfect.

However, on hearing that she was taking 10,000 units vitamin D per day, Joanne’s primary care physician was shocked: “What? Stop that immediately! You’re taking a toxic dose!” So Joanne called me to find out if this was true.

No, of course it’s not true. It’s not the dose that’s toxic, but the blood level it generates. Although it varies, vitamin D toxicity, as evidenced by increased blood calcium levels, generally does not even begin to get underway until at least 120-130 ng/ml, perhaps higher. Rarely, a dose of 2000 units per day will generate a level this high. In others, it may require 24,000 or more units per day to generate such a high level.

So it’s not the dose that’s toxic, but the blood level of 25-hydroxy vitamin D it generates.

Provided you and/or your doctor are monitoring 25-hydroxy vitamin D blood levels, the dose is immaterial. It’s the blood level you’re interested in.



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47 Responses to 10,000 units of vitamin D

  1. Anonymous says:

    I just trying to have ripped abs. I am not taking any supplements or anything like that but the literature here suggests that taking some substances could actually have an adverse affect on your body even though they are supposed to be healthy.

  2. mike V says:

    Ted, Dr D.
    I suggest that vitamin 2K should be considered in association with Vitamin D where the cancer mortality curve is in question.
    **
    http://www.lef.org/magazine/mag2009/jan2009_Vitamin-K-Protection-Against-Arterial-Calcification-Bone-Loss-Cancer-Aging_03.htm
    **
    note: I believe I am right insaying that the first 15 references cited in this article relate to cancer.
    Mike

    Mike V

  3. max says:

    good article.

  4. Anonymous says:

    I recently did the Vitamin D Council blood spot test. It cost $70.00 including shipping I think. It was painful and two weeks later, my finger still hurts. If I ever do another blood spot test, I'll try to draw blood from my forearm, although the test requires at least 2 large blood drops. I have no results yet. I am 114 lbs and take 2400 IU a day (softgels). I don't really plan to test ever again, especially on my finger, so I'll play it safe and keep my level around 40. Obviously, I'll have to adjust accordingly, once I get the results. I don't have the luxury of a good doctor. Doctors around here are virtually useless.

  5. Anonymous says:

    Hi there,
    Been researching Vit D here on the heartscan blog and others such as Vit D counsil, Dr. Ben Kims' site,getting good info to stay away from D2 of course.
    But this site, "The Peoples Chemist"- Shane Ellison and blog poster "Chuck" say we all should stay away from any man-made D3(sheep wool) included. They back it up stating specific chemical biological changes in the body. They say it just isn't the same and can do more harm in the long run. The site states basically that we should be using only food for Vit D3. meats, eggs, cod-liver oil(w/o the vitamins depleted or added)ect…
    This is real important for all of us if this is true. Please Heart scan Bloggers/Dr. Davis read the info @ Vit D on Shanes site… Thanks

  6. Anonymous says:

    Hi there,
    Been researching Vit D here on the heartscan blog and others such as Vit D counsil, Dr. Ben Kims' site,getting good info to stay away from D2 of course.
    But this site, "The Peoples Chemist"- Shane Ellison and blog poster "Chuck" say we all should stay away from any man-made D3(sheep wool) included. They back it up stating specific chemical biological changes in the body. They say it just isn't the same and can do more harm in the long run. The site states basically that we should be using only food for Vit D3. meats, eggs, cod-liver oil(w/o the vitamins depleted or added)ect…
    This is real important for all of us if this is true. Please Heart scan Bloggers/Dr. Davis read the info @ Vit D on Shanes site… Thanks

  7. Lynn D says:

    If our vite D levels show up low 20every year ,even when take 4000/day, then
    are we not absorbing or are we using it up. It sounds like some websearch showed up maybe
    additional testing such as also 1,25 OH in additon to the 25OH
    Thanks for any info

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